diff --git a/codex-rs/core/src/config.rs b/codex-rs/core/src/config.rs
index 87629d82..b43dc56b 100644
--- a/codex-rs/core/src/config.rs
+++ b/codex-rs/core/src/config.rs
@@ -480,10 +480,12 @@ impl Config {
         // Load base instructions override from a file if specified. If the
         // path is relative, resolve it against the effective cwd so the
         // behaviour matches other path-like config values.
-        let file_base_instructions = Self::get_base_instructions(
-            cfg.experimental_instructions_file.as_ref(),
-            &resolved_cwd,
-        )?;
+        let experimental_instructions_path = config_profile
+            .experimental_instructions_file
+            .as_ref()
+            .or(cfg.experimental_instructions_file.as_ref());
+        let file_base_instructions =
+            Self::get_base_instructions(experimental_instructions_path, &resolved_cwd)?;
         let base_instructions = base_instructions.or(file_base_instructions);
 
         let config = Self {
diff --git a/codex-rs/core/src/config_profile.rs b/codex-rs/core/src/config_profile.rs
index 176a9b15..d945d1df 100644
--- a/codex-rs/core/src/config_profile.rs
+++ b/codex-rs/core/src/config_profile.rs
@@ -1,4 +1,5 @@
 use serde::Deserialize;
+use std::path::PathBuf;
 
 use crate::config_types::ReasoningEffort;
 use crate::config_types::ReasoningSummary;
@@ -17,4 +18,5 @@ pub struct ConfigProfile {
     pub model_reasoning_effort: Option<ReasoningEffort>,
     pub model_reasoning_summary: Option<ReasoningSummary>,
     pub chatgpt_base_url: Option<String>,
+    pub experimental_instructions_file: Option<PathBuf>,
 }